Multivariate Data Analysis for Omics - 2 days course - Sweden
Multivariate Data Analysis for Omics
Multivariate data analysis is essential in the process of distilling information from the complex data sets involved in Omics. Huge datasets are reduced to informative plots and charts, enables scientific interpretation and insight. Discover how to build valid and predictive models based on data from in vivo metabolic profiles, with the latest multivariate techniques. The course is composed of lectures, demonstrations and computer exercises in SIMCA, based on real-life Omics datasets.
The objective of this course is to show how to convert data tables and matrixes to robust and reliable models for finding potential biomarkers in complex data structures. The aim is to present easy to understand pictures and graphs for model visualization and interpretation.
WHO SHOULD PARTICIPATE?
The course is intended for researchers involved in Omics and the important analysis of the data generated by single or multiple spectral instruments. No prior knowledge of statistics is assumed but some basic familiarity with the nature of spectroscopy data is required.
SELECTED COURSE CONTENT
• PCA to detect outliers, trends and patterns in Omics data.
• Model construction, interpretation and visualization.
• OPLS-DA for identification of potential biomarkers.
• S-plot (one model) and SUS-plot (two models) for biomarker identification.
09:00-9:10 Welcome and introduction
09:10-10:00 Introduction to Multivariate Data Analysis for OMICs
10:00-10:40 What is Principal Component Analysis (PCA)
10:40-10:50 Tea Break
10:50-11:20 Interpretation of PCA results using Omics Skin
11:20-12:00 Variable scaling, geometrical interpretation, and modelevaluation
13:30-14:10 Continued use of Omics Skin
15:30-15:40 Tea Break
16:50-17:00 Wrap up
09:00-10:00 MVDA regression techniques
10:00-10:40 Introduction to discriminant analysis
10:40-10-50 Tea Break
10:50-12:00 OPLS-DA (Orthogonal Partial Least Squares Discriminant Analysis), a state of art
technique for biomarkers identification
13:30-14:10 The use and interpretation of S‐plots and SUS‐plots
14:10-14:50 Validation of results from the model
14:50-15:00 Tea Break
15:00-16:50 Computer exercises and Discussion of participants' own data
16:50-17:00 Wrap up
COST AND CONDITIONS
Please note that at some course locations you are required to bring your own computer for the exercises. Instructions on how to install the program will be included in the final course information.
Included in the course fee (+ VAT) is coffee, lunch and course documentation.
Cancellations received later than two weeks before the course starts will not be refunded. For courses cancelled more than two weeks before the course starts, MKS Instruments AB will retain 10% of the course fee to cover administrative costs and the rest of the amount will be refunded.
Course participant(s) can be substituted by the registering company as long as MKS Instruments AB is notified.
MKS Instruments AB are providing courses based on a sufficient number of registrants. Therefore, MKS Instruments AB reserves the right to cancel the course 14 days prior to the course start date, if the number of registrants is too low. Full refund will be made to these registrants. A 10% discount will be made to any registrant(s) enrolling in the next available course.